Read original post by Michael Washington at LightSwitch Help Website
When deploying a LightSwitch web based application, the easiest method is to use the Publishing Wizard. However, the server that will host the LightSwitch application has to have the prerequisites installed.
LightSwitch creates a normal ASP.NET application that launces a Silverlight application, so it is possible to package in a way that allows a person to simply FTP it to a server, and then run a wizard through their web browser to configure it. This method is used by applications such as DotNetNuke and ADefHelpDesk for years.